Most sedating ssri

I don't want to increase my heart rate and am looking for one of the newer ones. There are more consistent studies supporting treatment of panic disorder with the SSRIs (Paxil, Zoloft, Celexa, Prozac), Effexor, or benzodiazepines (Xanax, Klonopin, Ativan).Paxil probably has the most sedative effects among the SSRIs.Certain differences between SSRIs are clinically significant.Also, SSRIs have very different molecular structures. Zoloft (Sertraline hydrochloride) was the second SSRI to come to market in the United States, and it was approved by the FDA in December 30, 1991. Paxil (Paroxetine hydrochloride) was the third SSRI to come to market in the United States and was approved by the FDA in December 29, 1992. Chemical structure of Paroxetine differs from other SSRIs by having a piperidine ring. I have some friends who take it, and they've said that it's sedating at first, but in some cases it wears off and in others it's fine if taken at bedtime. Maybe it's because of the continuous release formula, maybe the regular Paxil is more sedating.

However, now its marketing status is "Discontinued".

Stahl, MD, Ph D by e Med Expert staff Medical references reviewed: August, 2018 The most significant class of antidepressants marketed in recent years is the selective serotonin reuptake inhibitors (SSRIs).

The six SSRIs available in the United States are: The SSRIs represent the first rationally designed class of psychotropic medications.

All SSRIs are non-controlled prescription-only medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.

This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.

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